Even there are very limited immunological studies to date, Professor Flanagan explains the new paradigms in vaccinology exploring sex differences:
- Vaccines have non-targeted heterologous effects on innate and adaptive immunity
- These can alter susceptibility to non-vaccine targeted infectious diseases and can alter all cause mortality
- Females are more susceptible

Professor Flanagan concludes the slideset with the need to understand mechanisms in order to exploit beneficial and avoid harmful effects.