WAidid weekly suggested publication is the article recently published on PIDJ, Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients 

Summary

Viruses are an important cause of diarrhea in otherwise healthy children. Adenovirus is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). 2 patients with diarrhea and increasing stool viral load may be at risk for adenoviremia. Sustained adenoviremia is a specific and sensitive indicator of adenoviral disease after T-cell-replete HSCT.

The purpose of the study was to determine a viral load cutoff of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied.

Viral load >10⁶ copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively.

Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.

Authors: Srinivasan A., Klepper C., Sunkara A., Kang G., Carr J., Gu Z., Leung W., Hayden R.T.