- Tadolini M, Lingtsang RD, Tiberi S, Enwerem M, D'Ambrosio L, Sadutshang TD, Centis R, Migliori GB. First case of extensively drug-resistant tuberculosis treated with both delamanid and bedaquiline. Eur Respir J. 2016 Sep;48(3):935-8.
- Tadolini M, Lingtsang RD, Tiberi S, Enwerem M, D'Ambrosio L, Sadutshang TD, Centis R, Migliori GB. Cardiac safety of extensively drug-resistant tuberculosis regimens including bedaquiline, delamanid and clofazimine. Eur Respir J. 2016 Nov;48(5):1527-1529.
These articles describe the first XDR-TB case treated with both delamanid and bedaquiline reporting the rationale for prescribing both drugs. Despite difficulties encountered in the early phase of treatment, the interim treatment response is very good as the patient has been persistently sputum smear and culture negative since the second month of treatment. The article report also the actual debates about the risk of cardiotoxicity with QT prolonging drugs in salvage treatment for multidrug-resistant or XDR-TB patients.