The research activity of professor Ursula Grohmann (Perugia, Italy) deals with immunoregolatory mechanism in neoplasia and autoimmune and chronic inflammatory diseases. In this video, she speaks about the findings on juvenile diabetes following an experiment performed in 2003 on non obese diabetic mice (the most important experimental model for the study of human autoimmune diabetes), which resulted defective in the expression of the immunoregolatory enzyme IDO-1.