Acute haemophilus osteomyelitis is a rare condition in children. Professor Elena Chiappini illustrates epidemiology, risk factors, and diagnostic instruments. She then focuses on the necessityu to tailor the therapy on the child's clinical picture underlining that a short IV therapy is suggested in children under 3 months with no complications. Several prospective studies, indeed, seem to suggest the validity of short therapies in children in order to avoid complications due to intravenous catheter. Still, there are no guidelines in Europe establishing an homogeneous treatment.