The article suggested by WAidid this week, Genome-wide association studies in infectious diseases, has been published on The Pediatric Infectious Disease Journal on May 2016; this is the official publication of ESPID - European Society for Paediatric Infectious Diseases.
One of the most puzzling questions is why some children suffer from severe and life- threatening infections, while others who are exposed to the same pathogen remain uninfected, or suffer only from mild illness. There is now growing evidence that differences in host genetics play a major role in determining susceptibility and outcome of childhood infections, in addition to environmental factors. With subsequent human genetic variant mapping and improvements in technology , it became possible to search of genes influencing humans disease without any prior biological knowledge- a process now know as a genome-wide association study (GWAS). GWAS has emerged as a powerful tool to identify the genes underlying susceptibility and severity of many diseases.
AUTHORS: Seaby, Eleanor G.; Wright, Victoria J.; Levin, Michael